Cancer Articles

Dr. Ray Gin Dr Ray Gin seminar 10/10/12 at 7 pm

 “Is Your Life Creating Your Chronic Illness—Dr. Ray Gin” on October 10th at 7 pm.
Come listen to the FREE seminar and change your life!.

Is it possible that things you do and encounter everyday may be causing you to be sick?

This informative, interactive and fun workshop will help identify common things in your life that are contributing to your feeling unwell. You will be surprised by some of the things that are getting in your way of optimum health and feeling great.
Hope to see you.
Limited seating Call Mina 949-715-6789

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 “Is Your Life Creating Your Chronic Illness—Dr. Ray Gin” on October 10th at 7 pm.
Come listen to the FREE seminar and change your life!.

Is it possible that things you do and encounter everyday may be causing you to be sick?

This informative, interactive and fun workshop will help identify common things in your life that are contributing to your feeling unwell. You will be surprised by some of the things that are getting in your way of optimum health and feeling great.
Hope to see you.
Limited seating Call Mina 949-715-6789

UCLA researchers uncover stress accellerates breast cancer ~ “Don’t Worry Be Happy shirts agrees

Stress significantly accelerates breast cancer metastasis in mice, study shows for first time

UCLA researchers uncover how chronic stress reprograms immune cells to facilitate cancer progression

By Kim Irwin September 17, 2010 Category: Health Sciences, Research
Erica Sloan
Erica Sloan, first author of the study

Chronic stress acts as a sort of fertilizer that feeds breast cancer progression, significantly accelerating the spread of the disease in animal models, researchers at UCLA’s Jonsson Comprehensive Cancer Center have found.
Researchers discovered that stress is biologically reprogramming the immune cells that are trying to fight the cancer, transforming them from soldiers protecting the body against disease into aiders and abettors. The study found a 30-fold increase in cancer spread throughout the bodies of stressed mice, compared with those that were not stressed.
It has long been thought that stress fuels cancer growth in humans. This study provides a model that not only demonstrates that stress can speed up cancer progression but also details the pathway used to change the biology of immune cells that inadvertently promote the spread of cancer to distant organs, where it is much harder to treat.
The study is published in the Sept. 15 issue of the peer-reviewed journal Cancer Research.
“What we showed for the first time is that chronic stress causes cancer cells to escape from the primary tumor and colonize distant organs,” said the study’s first author, Erica Sloan, a Jonsson Cancer Center scientist and a researcher with the UCLA Cousins Center for Psychoneuroimmunology. “We not only showed that this happens, but we showed how stress talks to the tumor and helps it to spread.”
In addition to documenting the effects of stress on cancer metastasis, the researchers were also able to halt those effects by treating stressed animals with drugs that block the nervous system’s reprogramming of the metastasis-promoting immune cells, called macrophages.
Beta blockers, used in this study to shut down the stress pathways in the mice, are currently being examined in several large breast cancer databases for their role in the potential prevention of recurrence and cancer spread, said Dr. Patricia Ganz, director of cancer prevention and control research at the Jonsson Cancer Center. If preliminary findings indicate benefit, early-phase clinical trials are being considered at the Jonsson Cancer Center testing beta blockers as a means of preventing breast cancer recurrence.
Other healthy lifestyle behaviors, such as exercise and stress-reduction techniques, may also influence the biological pathways described in the study.
“We’re going to be focusing on younger women, because they may have a multitude of things weighing on them when they’re diagnosed with breast cancer. Younger women have more significant life demands and typically are under more stress,” Ganz said.
Ganz said her proposed research will focus on “host factors,” or things affecting the patient that may be aiding cancer progression and which could help explain why a group of patients with the same type and stage of disease have varying rates of recurrence and cancer spread.
“This study provides evidence for a biological relationship between stress and cancer progression and identifies targets for intervention in the host environment,” Ganz said. “Because of this study, we may be able to say to a patient in the future that if you follow this exercise regimen, meditative practice or take this pill every day, it will help prevent recurrence of your cancer. We can now test these potential interventions in the animal model and move those that are effective into the clinic.”
In Sloan’s study, mice with breast cancer were divided into two groups. One group of mice was confined in a small area for a short period of time every day for two weeks while the other group was not. The breast cancer cells were genetically engineered to include the luciferase gene, which is the molecule that makes a firefly glow. The growth and spread of the cancer in the mice was monitored using sensitive cameras that can pick up the luciferase signal. This allowed Sloan and her team to observe both the development of primary tumors and the spread of cancer throughout the body, said senior study author Steven Cole, an associate professor of hematology–oncology and a Jonsson Cancer Center researcher.
What was interesting, Cole said, was that the primary tumors did not seem to be affected by stress and grew similarly in both groups of mice. However, the stressed animals showed significantly more metastases throughout the body than did the control group. The cancer, in effect, acted differently in the stressed mice.
“This study is not saying that stress causes cancer, but it does show that stress can help support cancer once it has developed,” Cole said. “Stress helps the cancer climb over the fence and get out into the big, wide world of the rest of the body.”
Cole said Sloan detailed the biology of the stress-induced changes in the cancer cells along every step of the pathway, providing a roadmap by which stress promotes cancer metastasis. Additionally, Sloan proved that using beta blockers in stressed mice prevented the same cancer progression seen in the stressed mice that did not receive medication.
When cancer occurs, the immune system sends out macrophages to try to repair the tissue damage caused by the uncontrolled growth of cancer cells. The macrophages, in an attempt to help, turn on inflammation genes that are part of the normal immune response to injury. However, the cancer cells feed on the growth factors involved in a normal immune response. Blood vessels that are grown to aid healing instead feed the cancer the oxygen and nutrients it needs to grow and spread, and the extracellular matrix, which provides structural support for normal cells, is attacked during the immune response, helping the cancer cells escape from the primary tumor and spread to distant parts of the body.
“Many of the genes that promote cancer metastasis get turned on during the immune response by macrophages,” Cole said. “This study shows that stress signaling from the sympathetic nervous system enhances the recruitment of macrophages into the primary tumor and increases their expression of immune-response genes that inadvertently facilitate the escape of cancer cells into other parts of the body.”
Sloan showed that the beta blockers prevented the macrophages from hearing the signals sent by the sympathetic nervous system and stopped them from infiltrating the tumor and encouraging cancer spread.
The study was funded by the National Institutes of Health, the U.S. Department of Defense and the Jonsson Cancer Center.
UCLA’s Jonsson Comprehensive Cancer Center has more than 240 researchers and clinicians engaged in disease research, prevention, detection, control, treatment and education. One of the nation’s largest comprehensive cancer centers, the Jonsson Center is dedicated to promoting research and translating basic science into leading-edge clinical studies. In July 2010, the center was named among the top 10 cancer centers nationwide by U.S. News & World Report, a ranking it has held for 10 of the last 11 years.
For more news, visit the UCLA Newsroom and follow us on Twitter.

Don’t Worry Be Happy shirts at Stand Up 2 Cancer

Tonight was quite an inspiration and very emotional at Stand Up 2 Cancer. Thank you to NBC and Judith Lotz for the invite.   Thank You to P3R for the connections. Thank You Kevin for all of the Love you showed us all and continue to show us.  Thank You for  giving us all the driving force to help us help those with cancer, keeping us optimistic and HAPPY and help raise funds to find a cure. WE LOVE and MISS YOU Kevin!!

Let’s ALL STAND UP 2 CANCER and help each other and help find a cure.

We LOVE YOU ALL.  Thank You for your continued support.

Love Mina (MaryAnn) and the DWBHshirts.org Team

Camp Ronald McDonald for Good Times and DWBHshirts.org

Hi Mina,

Here are a couple pictures of me wearing my DWBH gear.

I first met Kevin at UCLA when I lived next door to him and the Pseudopod gang.  He became one of my dearest friends and I’ll always remember going to their shows, selling their cd’s and the endless nights laughing with them on their balcony or singing at the top of our lungs to random songs on the radio.  After we graduated our lives kind of drifted but we kept in touch here and there.

Over the past 8 summers I have volunteered at Camp Ronald McDonald for Good Times, a sleep-away camp for children with cancer and their siblings.  (http://www.campronaldmcdonald.org/)  I remember chatting with Kevin after his diagnosis about the camp and he said he would love to come and visit, even just to play a couple songs for the kids.  Unfortunately, our lives got in the way and we were never able to make that happen.

I was devastated to hear of Kevin’s passing last year.  Through my work with Camp Good Times, I’ve learned that cancer is a brutal, vicious and non-discriminating disease.  The world has lost too many people due to cancer and when it strikes a child or a young person, it hurts even more.  I have also learned, however, that each day is a choice.  I don’t have control over what happened yesterday or what may happen tomorrow and all I really have is NOW.  How am I going to live today?  I choose to laugh as much as possible and live my life to the fullest because I am constantly reminded that too many people don’t have that choice.

So I wear my DWBH shirts to honor my old friend, Kevin, and also to remind myself that today is ours.

Love,

Melissa Lee

“No longer forward nor behind,

I look in hope and fear.

But grateful take the good I find,

the best of now and here.”

-John G. Whittier

ps- The pictures were taken at our camp fundraiser in March and at our camp with an amazing cancer warrior in August!

DWBHshirts.org will participate in ACS San Diego “Relay for Life”

Hey everyone! My friend Camille and I (Genna Chapluk)  have started a team for San Diego’s Relay for Life, to benefit the American Cancer Society, and we could really use your support! Please visit the following link, where you can either join our team, donate to our team, or dedicate a luminaria bag for the event.

Time
August 21 at 9:00am – August 22 at 9:00am

Location Embarcadero North, Downtown San Diego

http://main.acsevents.org/site/TR?pg=team&fr_id=20537&team_id=751784

Our team is called “Don’t Worry Be Happy” in honor of my cousin Kevin Carlberg, who passed away from brain cancer last year. “Don’t Worry Be Happy” became Kevin’s life motto, and after he was diagnosed, he wore his “Don’t Worry Be Happy” shirt everywhere to to spread his optimism, positivity, and hope.

At Relay, our team will wear our Don’t Worry Be Happy Shirts, camp out overnight, and take turns walking around the track for twenty-four hours to raise money and awareness, and help the American Cancer Society. Whether you can commit to joining us for one lap, one hour, or the full 24 hours, we would love to have you on our team! If you can’t make it to the event, a donation would be tremendously appreciated. This is going to be an amazing event! Spread the word, and I hope to see many of you there!

Thanks everyone,
Don’t Worry, Be Happy!

Genna Chapluk

YOU CAN PURCHASE YOUR DON’T WORRY BE HAPPY Kevin Carlberg shirt to help support our cancer warriors at  http://DWBHshirts.org Online store